Evidence for a second messenger function of dUTP during Bax mediated apoptosis of yeast and mammalian cells
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولStructure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells.
Expression of the proapoptotic protein Bax under the control of a GAL10 promoter in Saccharomyces cerevisiae resulted in galactose-inducible cell death. Immunofluorescence studies suggested that Bax is principally associated with mitochondria in yeast cells. Removal of the carboxyl-terminal transmembrane (TM) domain from Bax [creating Bax (deltaTM)] prevented targeting to mitochondrial and comp...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2011
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2010.11.021